Mutant wasps were created in May 1998 after feeding on the pollen of Plant 42.[excerpt 1] Due to the accidental outbreak at the Arklay Laboratory, the staff were unable to control a mutant wasp nest, with at least one man succumbing to the poison. A wasp nest at a nearby abandoned hospital was also contaminated by suckling on the nectar of the Monster Plant, "Dorothy".
In Raccoon City, wasp nests were infected by unknown means. One nest was based within Raccoon University's ventilation tower, and was marked by Dr. Peter Jenkins as a source for V-Poison, a critical ingredient in creating Daylight.