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In the Resident Evil remake, they can survive getting hit from several weapons, and even a Rocket Launcher shot, eventually a player has to walk on them in order to kill them for good.
They are more aggressive and bigger in the Outbreak series than they were in Resident Evil (DS, original and remake).
Their attack in the Outbreak series will be harder to dodge, as in the Resident Evil remake a player can tap the buttons in order to make the wasps go away.
A good tactic to kill wasps is to play as Cindy, and when they're in mid-air ready to attack, to dodge and after the wasps passes through, to hit it with a Melee weapon (this has a chance to stun the wasp and drop it to the floor, allowing the player to stomp, shoot or beat it to death) or shoot it.
The wasp design most resembles the real-life Japanese giant hornet, which is geographically incorrect since those are native to Japan and wouldn't be found in the American Midwest. Yellowjackets, which vaguely resemble giant hornets, would be a more appropriate genus.