Dr. Wayne Li was an Umbrella USA researcher who was assigned to the Low Temperature laboratory in the NEST, a bioweapons research laboratory beneath Raccoon City. He was among the staff responsible for the Plant 43 project in the NEST's greenhouse, and worked under senior researcher Dr. Byron Cartwright.
During Operation: NESTWRECKER, the USS began shooting Umbrella employees in the facility, during which Dr. Li escaped into the Nap Room and shuttered himself behind a sleeping cell. However, after the facility lost power, he became trapped behind the shutter of his cell. Since his arm is later found hanging out the bottom of his cell, it can be assumed that he attempted to force his way out before finally succumbing to a T-virus infection.
The other members of the greenhouse team, meanwhile, were tackling the Monster Plant they were working on, and made plans to kill it with poisons but, without Dr. Li's help, they failed to produce an effective herbicide. The following week, survivors Leon S. Kennedy and Claire Redfield began exploring the facility in search of its research; one of the two was able to obtain his ID chip from his exposed arm hanging out of the botttom of the nap room shutters, gaining them Level 2 personel access. When power to the facility was restored, his reanimated corpse was freed and began roaming around the naproom.