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Prime universe
(Capcom's primary storyline)

Dr. Wayne Li was an Umbrella USA researcher who was assigned to the Low Temperature laboratory in the NEST, a bioweapons research laboratory beneath Raccoon City. He was among the staff responsible for the Plant 43 project in the NEST's greenhouse, and worked under senior researcher Dr. Byron Cartwright. According to corresponding emails from fellow researcher and coworker Rick Mendoza, the two were friends from high school.

During Operation: NESTWRECKER, the USS began shooting Umbrella employees in the facility, during which Dr. Li escaped into the Nap Room and shuttered himself behind a sleeping cell. Apparently futilely hoping to survive the assault by means of the shutters providing hiding cover to render him inconspicuous from the USS team, Dr. Li had also gone somewhat hysterical and manic upon these events, as evidenced by the last entry in his journal, but was immediately spotted trying to hide and was shot to death before it could close.

The other members of the greenhouse team, meanwhile, were tackling the Monster Plant they were working on, and made plans to kill it with poisons but, without Dr. Li's help, they failed to produce an effective herbicide. The following week, survivors Leon S. Kennedy and Claire Redfield began exploring the facility in search of its research; one of the two was able to obtain his ID chip from his exposed arm hanging out of the bottom of the nap room shutters, gaining them Level 2 personel access.  When power to the facility was restored, his reanimated corpse was freed and began roaming around the naproom.

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